Buffalo Bills vs Detroit Lions - Thu, 17 Sept 2026

Buffalo Bills

Home

Kickoff

Fri, 18 Sept

00:15

Detroit Lions

Away

59% Buffalo Bills41% Detroit Lions

Fri, 18 Sept • 00:15

Upcoming

NFL

Highmark Stadium, US

Buffalo Bills vs Detroit Lions Prediction

Q: When do Buffalo Bills and Detroit Lions play?

Buffalo Bills vs Detroit Lions kicks off on Friday, 18 September 2026 at 00:15 UTC at Highmark Stadium, US.

Why this pick

Fair price5% spread

Fairly priced: best 1.65 sits on the 1.60 consensus. Moderate 5% spread across 11 books.

Outcome

Buffalo Bills Win

1.65@ DraftKings

Most Probable59.4%

Place Bet

Win Prediction

Building price history

The consensus line fills in as bookmakers reprice this match. Check back soon.

Buffalo Bills59.4%

Detroit Lions40.6%

All Bets & Odds

Home Win

59.4%

Best 1.65

Away Win

40.6%

Best 2.46

Match Result Odds

Live odds across top bookmakers

#	Bookmaker	Home Win	Away Win	Payout %
1	Jack	1.58	2.29	93.5%
2	theScore Bet	1.65	2.35	96.8%
3	Caesars	1.63	2.34	96%
4	DraftKings	1.65	2.30	95.9%
5	PointsBet	1.63	2.35	96.2%
6	Fanatics	1.63	2.30	95.2%
7	BBallybet	1.61	2.35	95.4%
8	Betparx	1.61	2.35	95.4%
9	BetRivers	1.61	2.33	95.1%
10	BetMGM	1.60	2.40	96%
11	Ladbrokes	1.60	2.40	96%
12	Coral	1.60	2.40	96%
13	Bet365	1.60	2.40	96%
14	FanDuel	1.57	2.46	96%
15	Leovegas	1.57	2.25	92.5%
16	Williamhill	1.57	2.38	94.6%
17	Betsson	1.56	2.27	92.4%
18	Nordicbet	1.56	2.27	92.4%
19	Unibet Region	1.60	2.35	95.2%
20	Bovada Closed	1.63	2.35	96.1%
21	Mybookie Closed	1.58	2.33	94.3%
22	Paddy Power Closed	1.57	2.38	94.6%
23	Betfairsportsbook Closed	1.57	2.38	94.6%
24	Sportsbet Closed	1.56	2.45	95.3%

Live oddsAll odds are subject to changeShowing 6 of 24

Value & Signals

Best Price

Same bet, cheapest book. Line-shop this market across sportsbooks.

Outcome	Avg	Best	/ $100
Home Win	1.60	1.65 DraftKings	+$4.49	Bet
Away Win	2.34	2.46 BetMGM	+$11.61	Bet

Lineup & Player Match Stats

Lineup not available yet

Confirmed lineups appear closer to kick-off.

Market Analytics

Expected Score

28Buffalo Bills

25Detroit Lions

Market favors Buffalo Bills by 3 points

Derived from totals + spread lines

Market Activity

Low

Bookmakers0

Odds Updates (7d)0

Line movement (7d)

Home Win1.68—

Away Win2.46—

Match Stats History

Recent Form

Last 5

Buffalo Bills0W 0D 0L

No recent matches

Detroit Lions0W 0D 0L

No recent matches

Match Preview

Buffalo Bills vs Detroit Lions: Preview, Predictions & Betting Analysis

Buffalo Billsvs

Detroit Lions·NFL

59%Buffalo Bills win probability

Mediumconfidence

Match Overview

Buffalo Bills hold the edge on the numbers, but this NFL matchup is far from a foregone conclusion.

Buffalo Bills take on Detroit Lions in this NFL matchup, at Highmark Stadium, US on Thursday, September 17, 2026.

Market Read

Bookmakers make Buffalo Bills clear favourites at 1.65, a 59% chance across 11 books.

Best prices across the market: Buffalo Bills at 1.65 (59%), Detroit Lions at 2.40 (41%).

The model projects around 28-25 points, favouring Buffalo Bills by about 3 points (derived from totals + spread lines).

Value & Signals

There's a moderate 5% gap between the best and worst of 11 books.

Betting Verdict

For a longer shot, Detroit Lions are available at 2.40 (41%).

Our Pick: Buffalo Bills

Buffalo Bills are the market's pick at 59%. There's no standout price edge here, so it's a confidence call rather than a value one. Book agreement rates this a medium-confidence call.

Bet Home Win 1.65 at DraftKings

Frequently asked questions

Who will win Buffalo Bills vs Detroit Lions?

Our model makes Buffalo Bills the clear favourite at a 59% win probability versus Detroit Lions 41%. Best bet: Buffalo Bills to win at 1.65.

What are the odds for Buffalo Bills vs Detroit Lions?

The best available prices are Buffalo Bills 1.65, Detroit Lions 2.40. The best price you can back on Buffalo Bills is 1.65 with DraftKings, about a 61% chance, compared across 11 sportsbooks and updated live.

What is the predicted score for Buffalo Bills vs Detroit Lions?

Our model projects a final score of around Buffalo Bills 28-25 Detroit Lions, favouring Buffalo Bills by around 3 points, with a projected total of about 52.5 points (derived from totals + spread lines).

When do Buffalo Bills and Detroit Lions play?

Buffalo Bills vs Detroit Lions kicks off on Thursday, 17 September 2026 at 20:15 at Highmark Stadium, US.

Where can I bet on Buffalo Bills vs Detroit Lions?

Compare live odds from 11 sportsbooks on this page. DraftKings currently has the best price on Buffalo Bills at 1.65.

What's Next

Upcoming in NFL

Bet

Your Pick

Home Win

DraftKings

1.65

Stake

Payout+$64.50

$164.50

Probability: 60.8%

Bet at DraftKings

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